What are the most effective treatments for bullous pemphigoid?

Cochrane Skin is pleased to announce the publication of a new review, Interventions for bullous pemphigoid. This updated review included 14 randomized clinical trials with 442 participants diagnosed with bullous pemphigoid.

Key messages

  • Clobetasol propionate cream applied all over the skin is probably as effective as oral prednisone in treating bullous pemphigoid and may reduce mortality.  
  • Treatment with doxycycline (200 mg/day) provides acceptable blister control in the short term compared with the oral steroid prednisolone (0.5 mg/kg/day), and is superior in terms of long-term safety, including mortality.

To find out more, consult the full review in the Cochrane Library.