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A. INFECTIOUS DISEASES AFFECTING THE SKIN (41)
A0 Skin diseases caused by viruses: e.g.viral warts, herpes simplex (cold sores), herpes zoster (shingles), molluscum contagiosum; and diseases of suspected viral origin eg piytriasis rosea (25)
1. Preventive measures (0)
- reduction of transmission (0)
2. Medical treatments (19)
A20 Skin diseases caused by bacteria: e.g. impetigo, boils, folliculitis, cellulitis (Liaison with Cochrane Wounds Group for bacterial wound infections) (6)
1. Preventive (2)
- reduction of transmission (0)
- vaccination (0)
2. Medical treatments (4)
- alternative/complementary treatments (0)
3. Surgical procedures (0)
- incision and drainage (0)
A32-35 Tuberculosis and related infections of the skin: e.g.lupus vulgaris, atypical mycobacterial infection (fish tank granuloma etc) (0)
1. Preventive (0)
- reduction of transmission (0)
2. Medical treatments (0)
- antibiotic therapy (0)
3. Surgical (0)
- Excision (0)
A5 Skin diseases caused by fungi, e.g. candidosis (thrush), dermatophytosis (ringworm) (4)
1. Preventive (0)
- reduction of transmission : e.g. for tinea pedis (athlete's foot), tinea capitis (scalp ringworm) (0)
2. Medical treatments (4)
- alternative/complementary treatments (0)
3. Surgical treatments (0)
3. Surgical treatments (0)
B. SKIN CONDITIONS DUE TO ENVIRONMENTAL OR PHYSICAL INJURY (11)
B1 Pressure sores (0)
Please refer to Cochrane Wounds Group (0)
B2 Tattoos (0)
1. Preventive measures (0)
2. Removal (0)
- laser (0)
- surgical (0)
B5 Skin conditions caused or provoked by sunlight and ultraviolet radiation e.g. actinic (solar) keratoses, polymorphic light eruption, sun-induced skin ageing, photosensitivity dermatitis. Skin cancer is considered separately in sections X1 to X4. (11)
1. Preventive measures (2)
- public education campaigns (0)
2. Medical treatments (8)
- 5-fluoruracil for actinic keratoses (0)
- immunomodulators and anti-inflammatory agents (1)
Interventions for polymorphic light eruption (protocol stage)
- immunosuppressants (1)
Interventions for polymorphic light eruption (protocol stage)
- phototherapy, photochemotherapy (PUVA) (1)
Interventions for polymorphic light eruption (protocol stage)
C. DERMATITIS AND ECZEMA (37)
C1 Atopic dermatitis (atopic eczema, childhood eczema) (20)
1. Preventive measures (3)
2. Medical Treatments (17)
Other approaches (9)
- combinations of the above (2)
House dust mite reduction and avoidance measures for treating eczema (protocol stage)
Interventions for hand eczema (protocol stage)
- desensitisation (1)
Specific allergen immunotherapy for the treatment of atopic eczema (protocol stage)
- psychological and educational approaches (e.g. habit reversal, hypnosis) (2)
House dust mite reduction and avoidance measures for treating eczema (protocol stage)
- reduction in environmental allergens (1)
House dust mite reduction and avoidance measures for treating eczema (protocol stage)
Systemic treatments (4)
- antihistamines (1)
H1 antihistamines for eczema (protocol stage)
Topical treatments (creams/ointments applied directly to the skin) (4)
- calcineurin inhibitors (2)
Topical tacrolimus for atopic dermatitis (protocol stage)
- emollients (1)
Emollients for eczema (protocol stage)
-traditional chinese herbs (1)
Chinese herbal medicine for atopic eczema (protocol stage)
C2-C5 "Constitutional" Dermatitis e.g. seborrhoeic dermatitis (including dandruff, otitis externa), discoid eczema, pompholyx (11)
1. Prevention (0)
- use of soap substitutes (0)
2. Medical treatments (11)
- antibiotic therapy (0)
- antifungal agents (1)
Interventions for seborrhoeic dermatitis (protocol stage)
- combinations of the above (2)
Interventions for seborrhoeic dermatitis (protocol stage)
Interventions for hand eczema (protocol stage)
- topical corticosteroids and combinations with other agents (2)
Interventions for seborrhoeic dermatitis (protocol stage)
- topical lithium (1)
Interventions for seborrhoeic dermatitis (protocol stage)
C6-C8 Contact Dermatitis (allergic or irritant) e.g. nickel dermatitis, occupational hand dermatitis, "nappy rash" or "diaper rash". (6)
1. Preventive measures (4)
2. Medical treatments (2)
- combinations of the above (1)
Interventions for hand eczema (protocol stage)
Systemic treatments (0)
- azathioprine (0)
- cyclosporin (0)
- phototherapy, photochemotherapy (0)
- systemic corticosteroids (0)
- traditional chinese herbs (0)
Topical treatments (1)
- corticosteroid/antibiotic combinations (0)
- emollients (0)
- superficial radiotherapy (0)
- topical corticosteroids (0)
C9-CE Other eczematous reactions e.g. venous eczema (liaison with Cochrane Wounds Group), asteatotic dermatitis (0)
1. Prevention (0)
- emollients (0)
2. Medical treatment (0)
- emollients (including bath additives) (0)
- impregnated bandages (0)
- topical corticosteroids (0)
D. PSORIASIS AND OTHER KERATINISING DISORDERS (34)
D1 Psoriasis (34)
2. Medical treatments (33)
Alternative/complementary treatments (0)
- balneotherapy including spa waters and Dead Sea therapy (0)
- Chinese herbs (0)
- combinations of the above (0)
- dietary fish supplements (0)
- laser therapy (0)
- psychological approaches (0)
Systemic treatments (10)
- phototherapy (1)
Interventions for nail psoriasis (protocol stage)
- systemic retinoids (3)
Oral retinoids for psoriasis (protocol stage)
Interventions for nail psoriasis (protocol stage)
Topical treatments (23)
- anthralin (dithranol) (2)
Topical treatments for scalp psoriasis (protocol stage)
- combinations of the above (4)
Topical treatments for scalp psoriasis (protocol stage)
- emollients (1)
Topical treatments for scalp psoriasis (protocol stage)
- salicylic acid (2)
Topical treatments for scalp psoriasis (protocol stage)
- tacrolimus (2)
Topical treatments for scalp psoriasis (protocol stage)
- tar preparations (2)
Topical treatments for scalp psoriasis (protocol stage)
- topical corticosteroids (4)
Topical treatments for scalp psoriasis (protocol stage)
Interventions for nail psoriasis (protocol stage)
- topical retinoids (2)
Topical treatments for scalp psoriasis (protocol stage)
- vitamin D analogues (2)
Topical treatments for scalp psoriasis (protocol stage)
E. PAPULOSQUAMOUS DISORDERS INCLUDING LICHEN PLANUS; (6)
E0 Lichen planus (6)
- systemic corticosteroids (2)
Interventions for cutaneous lichen planus (protocol stage)
E6 Granuloma annulare (0)
- cutaneous injury including cryotherapy (0)
- intralesional corticosteroids (0)
- nicotinamide (0)
E8 Cutaneous sarcoidosis (0)
- antimalarial therapy (0)
- methotrexate (liaison with Cochrane Airways Group) (0)
- topical and intralesional corticosteroids (0)
F. URTICARIA AND OTHER INFLAMMATORY SKIN DISORDERS (4)
F1-F9 Urticaria (hives) and angio-oedema (2)
- anabolic steroids (for hereditary angio-oedema) (0)
- cyclosporin (0)
- dietary measures (0)
- oral H1 antihistamines (1)
H1-antihistamines for chronic urticaria (protocol stage)
G. DISORDERS OF SKIN COLOUR (14)
H. DISORDERS OF SKIN APPENDAGES (HAIR, NAILS, SWEAT GLANDS) (22)
H10 Excessive hair growth (hirsutism) (1)
2. Medical treatments (0)
- hormonal therapy ie anti-androgens such as spironolactone, cyproterone acetate (liaison with Cochrane Menstrual Disorders Group) (0)
H12 Hair loss e.g. alopecia areata ("alopecia"), androgenic alopecia (male-pattern balding) (5)
H3 Acne (5)
Alternative/complementary treatments (2)
Complementary therapies for acne vulgaris (protocol stage)
Light therapies for acne (protocol stage)
Oral treatments (1)
- hormonal therapy such as anti-androgen therapy (liaison with Cochrane Menstrual Disorders Group) (0)
Topical treatments (1)
- adapalene (0)
- azelaic acid (0)
- benzoyl peroxide (0)
- combinations of the above (0)
- topical antibiotics (0)
H6 Hidradenitis suppurativa and other disorders of the apocrine sweat glands (0)
1. Medical treatments (0)
- anti-androgen therapy (liaison with Cochrane Menstrual Disorders Group) (0)
- oral antibiotics (0)
- oral isotretinoin (0)
2. Surgical treatments (0)
- cryosurgery (0)
- excision of apocrine gland-bearing skin (0)
H7 Sweating disorders (6)
1. Medical treatments (4)
- iontophoresis (1)
Interventions for excessive sweating of unknown cause (protocol stage)
- oral anticholinergic therapy (1)
Interventions for excessive sweating of unknown cause (protocol stage)
J. DISORDERS INVOLVING THE SKIN'S BLOOD & LYMPHATIC VESSELS (0)
J1 Ectasias of blood vessels in the skin (dilated blood vessels) (0)
- injection of sclerosing agents (0)
- laser therapy (0)
J3 Cutaneous vasculitis (inflammation of blood vessels in the skin) (0)
- colchicine (0)
- dapsone (0)
- immunosuppressive and cytotoxic drugs (cyclosporin, cyclophosphamide) (liaison with Cochrane Musculoskeletal Diseases Group) (0)
- systemic corticosteroids (0)
J9 Oedema and lymphoedema (liaison with Cochrane Peripheral Vascular Diseases Group) (0)
JB Blushing and flushing reactions (0)
Medical treatments (0)
- antihistamines (0)
- propranolol (0)
JD Raynaud's disease ("white finger") and related disorders (liaison with Cochrane Peripheral Vascular Diseases Group and Cochrane Musculoskeletal Group) (0)
K. DISORDERS OF THE DERMIS AND SUBCUTANEOUS TISSUE (0)
K01 Cutaneous striae (stretch marks) (liaison with Cochrane Pregnancy and Childbirth Group) (0)
K80 Panniculitis (inflammation of subcutaneous fat) (0)
- antituberculous therapy (0)
- oral corticosteroids (0)
M. CONNECTIVE TISSUE AND IMMUNOBULLOUS AND RELATED; (26)
M0 Lupus erythematosus (7)
M1 Systemic sclerosis (systemic scleroderma) (liaison with Cochrane Musculoskeletal Diseases Group) (0)
- extracorporeal photochemotherapy (0)
- penicillamine (0)
- systemic corticosteroids (0)
M2 Morphoea and related conditions (4)
- intralesional treatments (1)
Interventions for morphea (protocol stage)
- intravenous treatments (1)
Interventions for morphea (protocol stage)
- systemic treatments (1)
Interventions for morphea (protocol stage)
- topical treatments (1)
Interventions for morphea (protocol stage)
M5 Dermatomyositis (liaison with Cochrane Musculoskeletal Diseases Group) (0)
- systemic immunosuppressive agents (0)
N. METABOLIC AND NUTRITIONAL DISORDERS AFFECTING THE SKIN (0)
N4 Porphyrias affecting the skin (0)
- antimalarials (0)
- venesection (0)
P. PSYCHOLOGICAL, PSYCHIATRIC AND RELATED DISORDERS OF THE SKIN (0)
P0 Pruritus and skin itching e.g. "senile pruritus", pregnancy itch, uraemic pruritus, nodular prurigo (0)
- alternative/complementary treatments (0)
- aspirin (liaison with Cochrane Pregnancy and Childbirth Group for itching in pregnancy) (0)
- emollients (0)
- opiate antagonists (0)
- phototherapy (0)
- use of non-biological washing powder (0)
Combination treatments (0)
Systemic interventions (0)
Topical interventions (0)
P1 Self-inflicted skin disease including dermatitis artefacta (0)
- antipsychotic agents (0)
- behaviour therapy (0)
- psychotherapy (0)
P3 Disorders of cutaneous image and perception including delusional psychosis affecting the skin (0)
- pimozide (0)
- psychiatric therapy (0)
S. GENETIC AND CHROMOSOMAL DISORDERS AFFECTING THE SKIN (1)
S4 Ichthyoses (inherited scaling disorders of the skin) (1)
- emollients (0)
- systemic retinoids (1)
Systemic retinoids for ichthyosis in children (protocol stage)
SA Epidermolysis bullosa (inherited blistering disorders of the skin) (0)
1. Medical treatments (0)
- phenytoin (0)
2. Surgical treatments (0)
- correction of deformity (0)
W. BIRTH MARKS AND DEVELOPMENTAL ABNORMALITIES OF THE SKIN (15)
X. TUMOURS AND CYSTS OF THE SKIN AND APPENDAGES (47)
X0, X3 Benign tumours of the skin e.g. seborrhoeic warts, benign "moles" (see also B5) (0)
- cryotherapy (0)
- laser therapy (0)
- surgical removal (0)
X1-X2 Non-melanoma cancer and precancer of the skin e.g. Bowen's disease, squamous cell carcinoma, basal cell carcinoma ("rodent ulcer") (40)
1. Preventive (6)
2. Medical treatment (10)
- interferon (2)
Interventions for actinic keratoses (protocol stage)
- other topicals (4)
Interventions for actinic keratoses (protocol stage)
Interventions for Bowen's Disease (protocol stage)
3. Surgical treatment (17)
- cryosurgery (4)
Interventions for actinic keratoses (protocol stage)
Interventions for Bowen's Disease (protocol stage)
- curettage and electrocautery (4)
Interventions for actinic keratoses (protocol stage)
Interventions for Bowen's Disease (protocol stage)
- laser surgery (3)
Interventions for Bowen's Disease (protocol stage)
- micrographic (Mohs') surgery (3)
Interventions for Bowen's Disease (protocol stage)
4. Other treatments (7)
- photodynamic therapy (4)
Interventions for actinic keratoses (protocol stage)
Interventions for Bowen's Disease (protocol stage)
X4 Malignant melanoma (7)
1.Preventive (2)
- preventative agents (2)
Cox-2 Inhibitors in the Prevention of Melanoma (protocol stage)
Y BENIGN AND MALIGNANT INFILTRATIONS OF THE SKIN (4)
Y2 Cutaneous T-cell lymphoma (mycosis fungoides (4)
- cytotoxic chemotherapy (1)
Interventions for mycosis fungoides (protocol stage)
- electron beam therapy (1)
Interventions for mycosis fungoides (protocol stage)
- photochemotherapy (1)
Interventions for mycosis fungoides (protocol stage)
- radiotherapy (1)
Interventions for mycosis fungoides (protocol stage)